HYBRID EVENT: You can participate in person at Orlando, Florida, USA or Virtually from your home or work.

3rd Edition of Global Conference on

Addiction Medicine, Behavioral Health and Psychiatry

October 24-26, 2022 | Orlando, Florida, USA

ce-approved
GAB 2019

Silencing microRNA 134 in ventral hippocampus attenuates anxiety like and depressionlike behaviors in cocaine extinction mice

Speaker at Global Conference on Addiction Medicine and Behavioral Health 2019 - Feifei Ge
Nanjing University of Chinese Medicine, China
Title : Silencing microRNA 134 in ventral hippocampus attenuates anxiety like and depressionlike behaviors in cocaine extinction mice

Abstract:

MicroRNA-134 (miR-134) is abundantly expressed in the hippocampus and play important roles in the process of brain development and neuropsychiatric disorders. The present study aims to explore whether miR-134 involves in cocaine exposure related psychiatric disorders and the mechanisms by which miR-134 influence addiction.  In models of cocaine conditioned place preference (CPP), we found an enhanced anxiety and depression levels in cocaine extinction mice, accompanied by a significant upregulation of miR-134 level specifically in the ventral hippocampus (vHP). In parallel, some potential target genes of miR-134 related synaptic plasticity and neurochemical environment, including BDNF and CREB are markedly reduced in the vHP. As expected, synaptic plasticity and microenvironment were impaired by cocaine addiction. Most importantly, local silencing miR-134 in the vHP ameliorated the abnormal behaviors and reversed almost all the above changes in molecules induced by cocaine extinction in the vHP. Thus, miR-134 signaling pathway might become a promising therapeutic target for treatment of addiction.

Biography:

Feifei Ge, Ph.D. was Associate professor, School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, China Research interest: Neuroplasticity and brain diseases. Our long-tern research goal is to understand the neural mechanisms underlying emotional and motivational responses. We focus on animal models related to drug addiction.

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