A gap between public understanding, cutting edge brain science and the practice of addiction treatment has created hardship for those suffering. New perspective replaces the term addiction with the new concept of a continuum of substance use. Substance Use Disorder (SUD) is now regarded as a manifestation of Reward Deficiency Syndrome (RDS), which contributes to a spectrum of disorders related to genetic polymorphisms, especially in regard to impulsive, addictive and compulsive behaviors. The new brain science of addiction requires neurological medical intervention and novel treatment with nutraceuticals, the building blocks of neurotransmission. Innovative alternative holistic and wellness therapies are proving to be beneficial in helping the sufferer thrive despite chronic neurological challenge.