HYBRID EVENT: You can participate in person at Baltimore, Maryland, USA or Virtually from your home or work.

5th Edition of Global Conference on

Addiction Medicine, Behavioral Health and Psychiatry

October 21-23, 2024 | Baltimore, Maryland, USA

GAB 2022

Dias Permeisari

Speaker at Addiction Medicine, Behavioral Health and Psychiatry 2022 - Dias Permeisari
Airlangga University, Indonesia
Title : Learn from the positive side of GHB in reducing alcohol dependence

Abstract:

Alcohol is a potent psychotropic depressant of the central nervous system that has neurogical impact leading to changes in several neuronal pathways, behavioral, and biological. Based on a report from WHO 2022, harmful consumption of alcohol can affect more than 200 health conditions, ranging from liver diseases, cancer, cardiovascular diseases, suicides, tuberculosis, HIV/AIDS, road injuries and violence, and even death with an incidence of 5.3% annually, globally. Some of the drugs that have received FDA approval for alcoholism are disulfiram, acomprosate, and naltrexone, while GHB has been approved to reduce alcohol dependence in Italy. Based on various systematic reviews and meta-analysis literatures, original articles, expert opinions in PUBMED and Cochrane, although by several studies the mechanism of its inhibition is strongly influenced by the presence of anesthetic drugs and calcium ion levels, GHB as an off-label drug given during abstinence has good efficacy in reducing alcohol dependence, the mechanism involves specific inhibition on central release of dopamine. However, GHB also has a high toxicity and abuse rate, so further studies are required to obtain an effective and safer substance.

What will audience learn from your presentation?

? GHB has a unique mechanism on dopaminergic neuron in inhibiting dopamine release to decrease alcohol craving

? Even GHB effectively decrease alcohol dependence based on Cochrane study, some studies was conducted to find out positive allosteric modulation of GHB to reduce the abuse rate of GHB, and the study still undergoing more and more

? Alcohol dependence experienced by some mechanisms

Biography:

The Author was currently studying at Airlangga Univeristy, Master degree in Clinical Pharmacy Department (as the last year of student). The number of her experiences in pharmacy hospital as a Pharmacy Manager in Mother and Child Hospital for 2 years and 1 year as a Pharmacy Manager in Private Hospital, also has an experience as a clinical pharmacy in another Private Hospital before she continues her master degree in the university. Besides her former work experiences and current study, she also has a project addressed to Prof Arthur Christopoulos Lab, Monash University Australia in Depression treatment.

Watsapp