Title : Learn from the positive side of GHB in reducing alcohol dependence
Abstract:
Alcohol is a potent psychotropic depressant of the central nervous system that has neurogical impact leading to changes in several neuronal pathways, behavioral, and biological. Based on a report from WHO 2022, harmful consumption of alcohol can affect more than 200 health conditions, ranging from liver diseases, cancer, cardiovascular diseases, suicides, tuberculosis, HIV/AIDS, road injuries and violence, and even death with an incidence of 5.3% annually, globally. Some of the drugs that have received FDA approval for alcoholism are disulfiram, acomprosate, and naltrexone, while GHB has been approved to reduce alcohol dependence in Italy. Based on various systematic reviews and meta-analysis literatures, original articles, expert opinions in PUBMED and Cochrane, although by several studies the mechanism of its inhibition is strongly influenced by the presence of anesthetic drugs and calcium ion levels, GHB as an off-label drug given during abstinence has good efficacy in reducing alcohol dependence, the mechanism involves specific inhibition on central release of dopamine. However, GHB also has a high toxicity and abuse rate, so further studies are required to obtain an effective and safer substance.
What will audience learn from your presentation?
? GHB has a unique mechanism on dopaminergic neuron in inhibiting dopamine release to decrease alcohol craving
? Even GHB effectively decrease alcohol dependence based on Cochrane study, some studies was conducted to find out positive allosteric modulation of GHB to reduce the abuse rate of GHB, and the study still undergoing more and more
? Alcohol dependence experienced by some mechanisms
