The future is now for precision genomic addiction medicine as a frontline modality for inducing "Dopamine Homeostasis" in Reward Deficiency Syndrome (RDS)

Title : The future is now for precision genomic addiction medicine as a frontline modality for inducing "Dopamine Homeostasis" in Reward Deficiency Syndrome (RDS)

Abstract:

Introduction: In this genomic era of addiction medicine, ideal treatment planning begins with genetic screening to determine neurogenetic antecedents of the Reward Deficiency Syndrome (RDS) phenotype. Patients suffering from endotype addictions, both substance and behavioral, and other mental health/comorbid disorders that share the neurobiological commonality of dopamine dysfunction, are ideal candidates for RDS solutions that facilitate dopamine homeostasis, addressing the cause, rather than symptoms.
Objective: Our goal is to promote the interplay of molecular biology and recovery as well as provide evidence linked to RDS and its scientific basis to primary care physicians and others.
Methods: This was an observational case study with a retrospective chart review in which an RDS treatment plan that utilized Genetic Addiction Risk Severity (GARS) analysis to evaluate neurogenetic challenges was used in order to develop appropriate short- and long-term pharmaceutical and nutraceutical interventions.
Results: A Substance Use Disorder (SUD) treatment-resistant patient was successfully treated utilizing the GARS test and RDS science.
Conclusion: The RDS Solution Focused Brief Therapy (RDS-SFBT) and the RDS Severity of Symptoms Scale (SOS) may provide clinicians with a useful tool for establishing neurological balance and helping patients to achieve self-efficacy, self-actualization, and prosperity.
Keywords: Dopamine Homeostasis; Genetic Addiction Risk Severity (GARS); Genomic Addiction Medicine; Neurogenetics; Precision Medicine; Pro-Dopamine regulation.

Biography:

Elizabeth Dale Gilley is a research scientist who focuses upon underlying neurogenetic and neurobiological syndrome which manifest as Substance Use Disorders and comorbid Mental Health Disorder Clusters.  The Elle Foundation 100 series in family genomics clearly demonstrates the Reward Deficiency Syndrome paradigm and how genomic applications  benefit RDS families over the generations. She is in her 6^th year of longitudinal studies for the 100s series.  She is in the data collection analysis phase of the 200s series, which will inform the design of a much larger study known as the EF300s.