Title : Neurochemical theory of epilepsy pathogenesis: Role of the blood-brain barrier
Abstract:
Background and aims: In epileptology, a huge layer of clinical facts have been accumulated, many of which have not received a proper explanation. An attempt to explain some of the clinical manifestations of epilepsy is presented.
Methods: Consideration of these clinical manifestations in the light of the proposed new hypotheses, theories.
Results: In the article, in light of the presented hypotheses about the pathogenesis of epilepsy the author considers certain clinical manifestations of epilepsy, touches upon the neurochemistry of behavior, as well as the neurotransmitter hypothesis of schizophrenia. In the context of this hypothesis, there are discussed the clinical signs of epilepsy such as forced normalization, reinforcement epilepsy activity during sleep deprivation, and other clinical manifestations of epilepsy. Two kinds of “clinical-electroencephalographic dissociation” are proposed. The presented theory also considers mental diseases and the biological antagonism of schizophrenia and epilepsy. The role of the blood-brain barrier in the development of epilepsy is considered. According to the author's assumption, the blood contains psychogenic and epileptogenic substances, the concentration of which in the blood is higher than their concentration in the brain. If the function of the blood-brain barrier is impaired, their content in the brain can increase and cause epilepsy or mental disorders. In addition to the antiepileptic system of the brain, the concepts of the borderline and extracerebral antiepileptic and antipsychotic systems are proposed.
Conclusion: The intensification of the development of neurochemical theories in epileptology will accelerate the creation of new antiepileptic drugs.
Keywords: Epilepsy, Neuro mediators, Forced normalization of electroencephalogram image, Behavior, Biological antagonism of schizophrenia and epilepsy, Blood-brain barrier
