Legalization trends have brought both opportunities and challenges in how cannabis is perceived and used. The discussion around cannabis use: medical and recreational implications now spans pharmacology, ethics, public policy, and mental health. While medical cannabis shows promise for chronic pain and certain neurological conditions, concerns remain about cognitive effects, dependency risk, and adolescent exposure. On the recreational side, varying potencies and delivery methods complicate regulation and health guidance. Research into endocannabinoid system interactions continues to evolve, shaping therapeutic and safety protocols. Clear distinctions between therapeutic and recreational use are essential for informed decision-making among clinicians and policymakers alike.