When conventional pharmacotherapy falls short, brain stimulation methods are increasingly being utilized. Neuromodulation techniques: TMS, DBS, and ECT offer evidence-based options for treatment-resistant depression, obsessive-compulsive disorder, and bipolar disorder. Transcranial magnetic stimulation (TMS) provides non-invasive stimulation with minimal side effects, while deep brain stimulation (DBS) targets specific circuits via implanted electrodes. Electroconvulsive therapy (ECT), though often misunderstood, remains highly effective in severe cases, especially in acute suicidal ideation or catatonia. Each method demands precise clinical evaluation and ethical considerations, particularly regarding consent and potential cognitive effects. Advances in imaging and targeting technologies are enhancing safety and efficacy, marking neuromodulation as a critical frontier in modern psychiatry for those in need of advanced intervention strategies.
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