Helping individuals break free from nicotine addiction requires a tailored approach that addresses both physiological dependency and behavioral patterns. Smoking cessation and nicotine dependence remain critical topics in addiction medicine due to their high prevalence and significant health impacts. Interventions now blend pharmacologic aids—such as nicotine replacement therapy, bupropion, and varenicline—with behavioral counseling and digital health tools. Socioeconomic factors, mental health, and comorbid addictions can affect quit rates, highlighting the importance of comprehensive care models. Public policies on taxation, advertising, and smoking bans have also influenced cessation efforts. Research continues to explore genetic predispositions and relapse mechanisms to enhance outcomes.