Synthetic compounds that mimic traditional drugs but skirt legal frameworks are complicating addiction landscapes. The proliferation of novel psychoactive substances and emerging drug trends poses significant risks due to unpredictable potency and side effects. These substances often evade detection by standard drug screens, challenging clinicians during diagnosis and treatment. From synthetic cannabinoids to designer stimulants, their impact can be severe, leading to hospitalizations, psychosis, or fatal overdoses. Monitoring systems and toxicological advancements are now essential in keeping pace with new variants. Public awareness campaigns, rapid policy adaptation, and global data sharing are crucial to curbing the spread and harm of these unpredictable substances.
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