Once marginalized, psychedelics and alternative therapies in psychiatry are now being re-evaluated through a scientific lens for their potential to treat resistant mental health conditions. Clinical trials using psilocybin, MDMA, and ketamine have shown promise in reducing symptoms of depression, PTSD, and end-of-life anxiety when paired with guided psychotherapy. These treatments often work differently from conventional medications, targeting neuroplasticity and emotional processing. Integration into psychiatric practice remains cautious but optimistic, with safety protocols, legal frameworks, and therapist training being carefully developed. Beyond psychedelics, interest in holistic alternatives like nutritional psychiatry, acupuncture, and neurofeedback is also growing. As the evidence base expands, psychiatry is beginning to embrace a more diverse toolkit that respects both scientific rigor and patient-centered preferences for innovative, individualized treatment.