Antidepressants can be a valuable component of substance dependence treatment, particularly for individuals with co-occurring depression or anxiety. Medications like selective serotonin reuptake inhibitors (SSRIs) help stabilize mood and reduce withdrawal symptoms, making the recovery process more manageable. However, careful monitoring is essential to prevent potential drug interactions or misuse. Combining antidepressant therapy with counseling and behavioral interventions ensures a holistic approach to treatment. While not a standalone solution, antidepressants play a supportive role in addressing the psychological dimensions of addiction, enhancing the effectiveness of comprehensive recovery plans.