Chronic pain management often involves opioids, which carry a high risk of addiction. Prolonged use can lead to tolerance, dependence, and misuse, complicating pain relief efforts. A comprehensive approach to managing this dual challenge includes multimodal therapies such as physical rehabilitation, cognitive-behavioral therapy, and non-opioid analgesics like NSAIDs and antidepressants. Emerging treatments like medical cannabis and neuromodulation techniques offer promising alternatives. Integrated care models, combining addiction treatment with pain management, are critical. Medication-assisted therapy (MAT) using buprenorphine or methadone helps stabilize opioid dependence while addressing pain. Patient education and regular monitoring reduce misuse risks, fostering sustainable recovery and improved quality of life.