Chronic pain management in individuals with substance use disorders presents a unique challenge. Traditional pain medications like opioids can exacerbate addiction issues, necessitating alternative approaches. Non-opioid medications, physical therapy, and psychological interventions such as cognitive-behavioral therapy are essential components of treatment. Mind-body techniques like meditation, acupuncture, and yoga also provide relief while minimizing the risk of dependency. A multidisciplinary approach, combining pain management with addiction treatment, ensures a balanced strategy that addresses both physical discomfort and the underlying substance use disorder, promoting long-term recovery and improved quality of life.