Chronic stress plays a significant role in addiction relapse, acting as both a trigger and a consequence of substance use. Stress disrupts the brain's reward pathways, increasing cravings and reducing the effectiveness of coping mechanisms. During recovery, stress can undermine an individual's motivation, leading to impulsive decision-making and emotional dysregulation. Cortisol, the stress hormone, exacerbates these challenges by reinforcing neural connections associated with addiction. Addressing chronic stress through mindfulness, cognitive-behavioral therapy (CBT), and relaxation techniques is crucial in minimizing relapse risks. Building resilience through stress management strategies not only aids in recovery but also fortifies an individual’s capacity to resist future triggers. Understanding the interplay between chronic stress and addiction highlights the need for comprehensive treatment plans that focus on emotional regulation and long-term behavioral change.