Drug use disorders often lead to cognitive impairments, affecting memory, attention, and executive functions. Substances like opioids, stimulants, and alcohol disrupt neural pathways, particularly in the prefrontal cortex and hippocampus. These cognitive deficits hinder decision-making, problem-solving, and impulse control, complicating recovery efforts. Rehabilitation programs frequently include cognitive-behavioral strategies and neurocognitive rehabilitation to address these deficits. Over time, abstinence and supportive therapies can promote neuroplasticity, aiding in cognitive recovery. Recognizing and addressing these impairments early in treatment is vital for fostering long-term recovery and improving quality of life.