6th Edition of Global Conference on
Addiction Medicine, Behavioral Health and Psychiatry
October 20-22, 2025 | Orlando, Florida, USA
Cross-Tolerance in Substance Use
Cross-tolerance occurs when the use of one substance reduces sensitivity to another, often due to overlapping mechanisms of action. For example, tolerance to alcohol may result in reduced responsiveness to benzodiazepines, as both affect the GABAergic system. This phenomenon complicates treatment and increases the risk of overdose when individuals switch or combine substances to achieve the desired effect. Cross-tolerance is a significant challenge in managing polysubstance use disorders, as it may necessitate higher doses of medications for effective treatment, increasing potential side effects. Treatment strategies include careful assessment of cross-tolerance patterns, gradual tapering protocols, and alternative medications that bypass tolerance mechanisms. Recognizing cross-tolerance is critical in designing safer and more effective addiction management plans.
Nile Stanley
University of North Florida, United States
Ann Marie Leonard Zabel
Curry College, United States
Denis Larrivee
University of Navarra, Spain
Scharbach Hugues
Paris University, France
Alphonsus Obayuwana
Triple-H Project LLC, United States
Jana Furstova
Palacký University Olomouc, Czech Republic
Alexander Kharibegashvil
Telavi State University, GeorgiaSubmit your abstract Today
Title : Decoding aggression, violence, and substance use in adolescents with conduct disorders: Neurochemical pathways and interventions
Ann Marie Leonard Zabel, Curry College, United States
Title : Integrative addiction and mental health wellness lecture
John Giordano, Life Enhancement Recovery Center, United States
Title : Step one therapy
Ashton Christopher, Center for Recovery, Canada
Title : Addiction rehabilitation & recovery: Pathways to healing and resilience
Sindu Padmanabhan, Bharathiar University, India
Title : Tailoring biblio-poetry therapies using AI and biofeedback for addiction treatment
Nile Stanley, University of North Florida, United States
Title : The A-B-C of happiness coaching
Alphonsus Obayuwana, Triple-H Project LLC, United States