7th Edition of Global Conference on
Addiction Medicine, Behavioral Health and Psychiatry
October 19-21, 2026 | Boston, Massachusetts, USA
Cross-Tolerance in Substance Use
Cross-tolerance occurs when the use of one substance reduces sensitivity to another, often due to overlapping mechanisms of action. For example, tolerance to alcohol may result in reduced responsiveness to benzodiazepines, as both affect the GABAergic system. This phenomenon complicates treatment and increases the risk of overdose when individuals switch or combine substances to achieve the desired effect. Cross-tolerance is a significant challenge in managing polysubstance use disorders, as it may necessitate higher doses of medications for effective treatment, increasing potential side effects. Treatment strategies include careful assessment of cross-tolerance patterns, gradual tapering protocols, and alternative medications that bypass tolerance mechanisms. Recognizing cross-tolerance is critical in designing safer and more effective addiction management plans.
Frederick J Goldstein
Philadelphia College of Osteopathic Medicine, United States
Nile Stanley
University of North Florida, United States
Ann Marie Leonard Zabel
Curry College, United States
John Michael Weber
Trauma Healed Life Coach, United States
Denis Larrivee
University of Navarra, Spain
Steve Cohen
Medvesta Hypnosis Healthcare, United States
Andrew Drasen
A Vision of Hope Media, United StatesSubmit your abstract Today
Title : The storm within: Neuropsychological insights into dysregulation and substance use in the adolescent brain
Ann Marie Leonard Zabel, Curry College, United States
Title : Integrating bibliopoetry therapy and digital health technologies for inflammation management: A neuropsychosomatic perspective
Nile Stanley, University of North Florida, United States
Title : Trauma: Till death do us part
John Michael Weber, Trauma Healed Life Coach, United States
Title : PIVOT: Predictive intervention for vaping using resonance modeling of oscillatory, psychological, and trigger dynamics
Aadya, Issaquah High School, United States
Title : Beyond the myths: Bipolar disorder, recovery, and the power of compassionate care
Pakesta Washington, Washington Elite Nursing Consultants, United States
Title : Addiction and the failure of meaning-forming
Jenni Guentcheva, GTI, United States