Drug-induced cognitive impairments occur when substances like alcohol, stimulants, or opioids alter brain function, leading to difficulties in memory, attention, or decision-making. Chronic use disrupts neural pathways, particularly in the prefrontal cortex and hippocampus, responsible for executive functions and memory consolidation. These impairments can hinder daily activities, learning abilities, and social interactions. Cognitive deficits vary by substance and usage patterns but can sometimes persist even after cessation, emphasizing the importance of early intervention. Treatment often includes detoxification, cognitive rehabilitation therapies, and neuroprotective medications to restore brain health. Understanding the mechanisms of drug-induced cognitive impairments aids in developing targeted strategies to mitigate long-term effects and improve the quality of life for affected individuals.