Substance use disorders (SUDs) significantly affect neurodevelopment, particularly when substance exposure occurs during adolescence—a critical period for brain maturation. Substances like alcohol, cannabis, and stimulants disrupt neural pathways, impairing cognitive functions such as memory, decision-making, and emotional regulation. Prenatal exposure to drugs also leads to long-term developmental challenges in children, including behavioral and learning disorders. Neuroimaging studies reveal structural and functional abnormalities in the brain's prefrontal cortex and limbic system. Early intervention, prevention programs, and cognitive rehabilitation are essential to mitigate these impacts and promote recovery.