Psycho-oncology addresses the psychological and emotional challenges faced by cancer patients, including the intersection with substance use disorders (SUDs). Cancer diagnosis and treatment often lead to emotional distress, prompting some individuals to misuse substances as a coping mechanism. Conversely, prolonged substance use increases cancer risks due to carcinogenic exposure and weakened immune responses. Integrating SUD screening into oncology care allows for early identification and intervention. Multidisciplinary approaches, involving oncologists, psychiatrists, and addiction specialists, ensure holistic care. Tailored treatments that address both cancer-related distress and substance use can improve quality of life and treatment outcomes for affected individuals.