Substance use disorders (SUDs) fundamentally alter the brain's reward system, which is primarily governed by dopamine. Drugs hijack this system, providing exaggerated rewards that surpass natural stimuli, such as food or social interaction. Over time, this leads to diminished sensitivity, making ordinary pleasures less rewarding. The imbalance in reward processing perpetuates compulsive drug-seeking behaviors. Neuroimaging studies reveal significant changes in brain regions like the nucleus accumbens and prefrontal cortex, which regulate motivation and decision-making. Treatment approaches aim to recalibrate the reward system through behavioral therapies and medications, promoting the restoration of normal functioning.
Title : The storm within: Neuropsychological insights into dysregulation and substance use in the adolescent brain
Ann Marie Leonard Zabel, Curry College and NEALAC Clinic , United States
Title : What to do when a tragedy strikes
Alphonsus Obayuwana, Triple-H Project LLC, United States
Title : The effect of Balint training on self-efficacy and empathy among medical students and the moderator role of personality traits and choice of specialty
Meni Koslowsky, Ariel University, Israel
Title : Genetic decoupling and global regulatory failure in diseases of agency
Denis Larrivee, University of Navarra, Spain
Title : Dr Jekyll and Mr. Hyde revealed: Tales from the default mode network
Christopher Ashton, TeDDs on Chapel, Centre for Recovery, Canada
Title : An unusual perspective for understanding and preventing bulimia relapse: Unhealthy sibling loyalty
Karen Gail Lewis, Private Practice, United States