Substance use disorders (SUDs) fundamentally alter the brain's reward system, which is primarily governed by dopamine. Drugs hijack this system, providing exaggerated rewards that surpass natural stimuli, such as food or social interaction. Over time, this leads to diminished sensitivity, making ordinary pleasures less rewarding. The imbalance in reward processing perpetuates compulsive drug-seeking behaviors. Neuroimaging studies reveal significant changes in brain regions like the nucleus accumbens and prefrontal cortex, which regulate motivation and decision-making. Treatment approaches aim to recalibrate the reward system through behavioral therapies and medications, promoting the restoration of normal functioning.
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Nile Stanley, University of North Florida, United States
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Aadya, Issaquah High School, United States
Title : The storm within: Neuropsychological insights into dysregulation and substance use in the adolescent brain
Ann Marie Leonard Zabel, Curry College, United States
Title : Addiction and the failure of meaning-forming
Jenni Guentcheva, GTI, United States
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Alphonsus Obayuwana, Triple-H Project LLC, United States
Title : Reward deficiency syndrome solution patient claims ‘dopamine homeostasis’ provided the neurological stability to begin focusing upon healing psychic fracture associated with chronic post-traumatic stress disorder dissociative multiplicity
Elizabeth Dale Gilley, The Elle Foundation, United States