Substance dependence significantly impairs self-control, rooted in disruptions in executive functioning and emotional regulation. Prolonged substance use alters brain structures like the prefrontal cortex and anterior cingulate cortex, reducing the ability to resist cravings or delay gratification. These deficits manifest in compulsive drug-seeking behaviors despite adverse consequences. Interventions like cognitive-behavioral therapy (CBT) aim to rebuild self-regulation skills through techniques such as impulse control training and coping strategies for triggers. Mindfulness-based practices also help individuals regain focus and manage emotional distress. By addressing self-control deficits, treatment can empower individuals to break the cycle of addiction and regain autonomy over their actions.