Substance use disorders (SUDs) are profoundly influenced by social determinants such as socioeconomic status, education, employment, housing stability, and access to healthcare. Poverty and unemployment increase vulnerability to SUDs by exacerbating stress and limiting access to support systems. Educational disparities affect awareness about substance risks, while unstable housing may perpetuate environments conducive to drug use. Discrimination and social marginalization also heighten susceptibility by fostering isolation and emotional distress. Furthermore, cultural norms and peer influences play pivotal roles in shaping attitudes toward substance use. Addressing these social determinants through community-based interventions, policy reforms, and equitable access to healthcare is crucial to reducing the prevalence and impact of SUDs.