Substance use is intricately linked to chronic health conditions, significantly impacting physical and mental well-being. Prolonged substance abuse can lead to liver disease, cardiovascular problems, and respiratory issues, depending on the substance. Additionally, conditions like diabetes, hypertension, and chronic pain often coexist with substance use disorders, creating complex treatment challenges. The interplay between substance use and chronic illness requires integrated care that addresses both conditions simultaneously. Multidisciplinary approaches, including medication-assisted treatment (MAT), lifestyle interventions, and behavioral therapies, are essential. Educating patients about the bidirectional impact of substance use and chronic diseases can improve adherence to treatment plans and enhance overall health outcomes.