Detoxification is the cornerstone of treatment for substance use disorders, aimed at safely clearing substances from the body. This medically supervised process addresses acute withdrawal symptoms, which can range from mild discomfort to life-threatening conditions. Effective protocols involve the use of medications like methadone, buprenorphine, or benzodiazepines to manage symptoms and stabilize patients. Nutritional support, hydration, and vitamin supplementation are vital in restoring the body's depleted reserves. Emotional and psychological care, including counseling and stress management techniques, are often integrated to address underlying issues contributing to substance use. Although detoxification does not resolve the psychological aspects of addiction, it lays the groundwork for comprehensive rehabilitation. Tailored detox programs that consider the individual’s substance of choice, medical history, and co-occurring conditions significantly improve outcomes, ensuring a smoother transition to long-term recovery and preventing potential relapses.