Genetic Predispositions to Substance Use Disorders

Genetics play a significant role in the development of substance use disorders, with heritability estimates ranging from 40% to 60%. Variants in genes related to dopamine regulation, impulse control, and stress response can increase susceptibility to addiction. While genetic predisposition doesn’t guarantee addiction, it interacts with environmental factors like trauma and peer influence. Advances in genomics have identified markers that may predict addiction risk, paving the way for personalized prevention strategies. Genetic counseling and tailored interventions, such as targeted therapies or early behavioral support, can mitigate risks for those with a family history of addiction.