Substance use disorders can leave lasting effects on mental health, even after cessation. Prolonged substance use alters brain chemistry, often resulting in mood disorders like depression or anxiety. Cognitive impairments, memory issues, and increased susceptibility to psychiatric conditions such as psychosis or bipolar disorder are common. These effects stem from neurotoxicity, disrupted neurotransmitter balance, and structural brain changes caused by substances. Addressing these long-term impacts requires an integrative approach, combining psychotherapy, medication, and lifestyle changes. Recovery programs emphasizing holistic care, such as mindfulness, physical activity, and social support, can help mitigate these enduring mental health challenges.