Substance dependence is deeply rooted in the brain's neuroanatomy, particularly involving the reward system, which includes the nucleus accumbens, prefrontal cortex, and ventral tegmental area. These structures regulate pleasure, motivation, and impulse control. Drugs like cocaine, opioids, and alcohol hijack this system by artificially increasing dopamine levels, reinforcing addictive behaviors. Over time, chronic use leads to structural and functional changes, such as reduced gray matter in the prefrontal cortex, impairing decision-making and self-regulation. Neuroplasticity plays a dual role in dependence and recovery, with targeted therapies focusing on rewiring these neural circuits to restore normal functioning.
Title : The storm within: Neuropsychological insights into dysregulation and substance use in the adolescent brain
Ann Marie Leonard Zabel, Curry College and NEALAC Clinic , United States
Title : The effect of Balint training on self-efficacy and empathy among medical students and the moderator role of personality traits and choice of specialty
Meni Koslowsky, Ariel University, Israel
Title : Sexualizing anxiety and anxiolytic sex: Misattribution of arousal
Sam Vaknin, Commonwealth Institute of Advanced Professional Studies, United Kingdom
Title : Dr Jekyll and Mr. Hyde revealed: Tales from the default mode network
Christopher Ashton, TeDDs on Chapel, Centre for Recovery, Canada
Title : Integrating bibliopoetry therapy and digital health technologies for inflammation management: A neuropsychosomatic perspective
Nile Stanley, University of North Florida, United States
Title : Addiction and the failure of meaning-forming
Jenni Guentcheva, GoodNeighbor LLC, United States