Substance dependence is deeply rooted in the brain's neuroanatomy, particularly involving the reward system, which includes the nucleus accumbens, prefrontal cortex, and ventral tegmental area. These structures regulate pleasure, motivation, and impulse control. Drugs like cocaine, opioids, and alcohol hijack this system by artificially increasing dopamine levels, reinforcing addictive behaviors. Over time, chronic use leads to structural and functional changes, such as reduced gray matter in the prefrontal cortex, impairing decision-making and self-regulation. Neuroplasticity plays a dual role in dependence and recovery, with targeted therapies focusing on rewiring these neural circuits to restore normal functioning.
Title : The storm within: Neuropsychological insights into dysregulation and substance use in the adolescent brain
Ann Marie Leonard Zabel, Curry College, United States
Title : Integrating bibliopoetry therapy and digital health technologies for inflammation management: A neuropsychosomatic perspective
Nile Stanley, University of North Florida, United States
Title : Trauma: Till death do us part
John Michael Weber, Trauma Healed Life Coach, United States
Title : Addiction and the failure of meaning-forming
Jenni Guentcheva, GTI, United States
Title : Beating the blues today
Steve Cohen, Medvesta Hypnosis Healthcare, United States
Title : Reduction of chronic neuropathic pain by a THC-CBD combination capsule: ongoing pilot study
Frederick J Goldstein, Philadelphia College of Osteopathic Medicine, United States